List of publications by Dr. Suresh I.S. Rattan
Key words: Aging, ageing, anti-aging, gerontogene,
vitagene, stress response, heat shock, hormesis, protein modification,
kinetin, zeatin, cytokinins, gerontology, biogerontology, longevity,
Danish keywords: aldring, alderdom, antirynker,
ældning
Research Papers and Review Articles
2008
179. Rattan, S.I.S., Fernandes, R.A., Demirovic, D., Dymek, B. and Lima, C. F. Heat stress and hormetin-sinduced hormesis in human cells: effects on aging, wound healing, angiogenesis and differentiation. Dose Response (in press)
178. Rattan, S.I.S. Principles and practice of hormetic treatment of aging and age-related diseases. Human and Experimental Toxicology, 27: 151-154, 2008.
177. Rattan, S.I.S. Celluar senescence in vitro. Encyclopedia of Life Sciences, 2008. (doi: 10.1002/9780470015902.a0002567.pub2)
176. Berge, U., Kristensen, P. and Rattan, S.I.S. Hormetic modulation of differentiation of normal human epidermal keratinocytes undergoing replicative senescence in vitro. Experimental Gerontology, 43: 658-662, 2008. (doi: 10.1016/j.exger.2007.12.009)
175. Rattan, S.I.S. Increased molecular damage and heterogeneity as the basis of aging. Biochemical Journal, 389: 267-272, 2008.
174. Rattan, S.I.S. Hormesis in aging. Ageing Research Reviews, 7: 63-78, 2008.
2007
173. Barciszewska, M.Z., Barciszewska, A.M. and Rattan, S.I.S. TLC-based detection of methylated cytosine: application to aging epigenetics. Biogerontology, 8, 673-678, 2007.
172. Rattan, S.I.S., Sejersen, H, Fernandes, R.A. and Luo, W. Stress mediated hormetic modulation of wound healing and angiogenesis in human cells Annals of the New York Academy of Sciences, 1119: 112-121, 2007.
171. Rattan, S.I.S. The science of healthy aging: genes, milieu, and chance. Annals of the New York Academy of Sciences, 1114: 1-10, 2007.
170. Singh, R., Kølvraa, S. and Rattan, S.I.S. (2007) Genetics of
longevity with emphasis on the relevance of HSP70 as candidate genes.
Frontiers in Bioscience,
12: 4504-4513, 2007.
169. Berge,
U., Behrens, J. and
Rattan, S.I.S Sugar-induced
premature aging and altered differentiation in human epidermal
keratinocytes
Annals of the New York Academy of
Sciences, 1100: 524-529, 2007.
168.
Sejersen,
H and
Rattan, S.I.S Glyoxal-induced
premature senescence in human fibroblasts. Annals of the New York Academy of
Sciences, 1100: 518-523, 2007.
167.
Rattan, S.I.S.
and Ali, R.E. Hormetic
prevention of molecular damage during cellular aging of human skin
fibroblasts and keratinocytes. Annals
of the New York Academy of Sciences, 1100: 424-430, 2007.
166.
Rattan, S.I.S.
(2007)
Homeostasis, homeodynamics, and aging. In: Encyclopedia
of Gerontology, (2nd edition; edited by J. Birren),
pp.
696-699
Elsevier Inc. UK.
2006
164. Bhattacharya, K. and Rattan, S.I.S. Dietary fats and age-related diseases. In: Prevention and Treatment of Age-related Diseases (Editors: S.I.S. Rattan and M. Kassem), pp. 335-356; Springer, Dordrecht, The Netherlands., 2006.
164. Rattan, S.I.S. Biological causes of aging and age-related diseases. In: Prevention and Treatment of Age-related Diseases (Editors: S.I.S. Rattan and M. Kassem), pp. 1-13; Springer, Dordrecht, The Netherlands, 2006.
163. Rattan, S.I.S. Theories of biological
aging: genes, proteins and free radicals. Free Radical Research,
40: 1230-1238, 2006.
162. Singh, R., Kølvraa, S., Bross, P., Jensen, U.B.,
Gregersen, N., Tan, Q., Knudsen, C., and Rattan,
S.I.S.
Reduced heat shock response in human mononuclear
cells during aging and its association with polymorphisms in HSP70
genes.
Cell Stress and Chaperones, 11: 208-215,
2006.
161. Deocaris, C.C., Shrestha,
B.G., Kraft, D.C., Yamasaki, K., Kaul, S.C., Taira, K., Rattan, S.I.S. and
Wadhwa, R. Geroprotection by glycerol: insights to its mechanisms and
clinical potentials. Annals
of the New York Academy of Sciences,
1067: 488-492,
2006.
160. Gonzalez-Dosal, R.,Sørensen, M.D., Clark,
B.F.C., Rattan, S.I.S. and Kristensen, P. Phage displayed antibodies
for
the detection of glycated proteasome in aging cells.
Annals of the New York Academy of Sciences,
1067: 474-478, 2006.
159.
Nørgaard, R., Kassem, M., and Rattan, S.I.S. Heat shock-induced
enhancement of osteoblastic differentiation of hTERT-immortalized
mesenchymal stem cells.
Annals of the New York Academy of Sciences, 1067: 443-447,
2006.
158.
Kraft, D.C., Deocaris, C.C. Wadhwah, R
and Rattan, S.I.S.
Preincubation with the proteasome inhibitor MG-132 enhances proteasome
activity via the Nrf2 transcription factor in aging human skin fibroblasts.
Annals of the New York Academy of Sciences,
1067: 422-426, 2006.
157. Ali, R.E. and Rattan, S.I.S. Curcumin’s
biphasic hormetic response on proteasome activity and heat shock protein
synthesis in human keratinocytes. Annals
of the New York Academy of Sciences
1067: 394-399, 2006.
156. Nielsen, E.R., Eskildsen-Helmond, Y.E.G.
and Rattan, S.I.S. MAP kinases and heat shock-induced hormesis in human
fibroblasts during serial passaging in vitro.
Annals of the New York Academy of Sciences
1067: 343-348, 2006.
155. Berge, U., Kristensen, P. and Rattan,
S.I.S. Kinetin-induced differentiation of normal human keratinocytes
undergoing aging in vitro. Annals of the
New York Academy of Sciences
1067: 332-336, 2006.
154. Singh, R., Kølvraa, S., Bross, P., Christensen, K., Gregersen, N.,
Tan, Q., Jensen, U.B., Eiberg, H and Rattan,
S.I.S. Heat shock protein 70 genes and human longevity: a view from
Denmark.
Annals of the New York Academy of
Sciences 1067: 301-308, 2006.
153. Kraft, D.C., Deocaris, C.C. and Rattan, S.I.S. Proteasomal oscillation
during mild heat shock in aging human skin
fibroblasts.
Annals of the New York Academy of Sciences
1067: 224-227,
2006.
152. Rattan, S.I.S.
Principles of ageing and practice of anti-ageing therapies.
Asian
Journal of Experimental Sciences, 20:
17-26, 2006.
2005
151. Rattan, S.I.S. Hormetic
modulation of aging and longevity by mild heat stress. Dose Response,
3, 535-546, 2005.
150. Olshansky, S.J. and Rattan, S.I.S. What determines
longevity: metabolic rate or stability?
Discovery Medicine, 5, 359-362, 2005.
149. Olshansky, S.J. and Rattan, S.I.S. At the heart of
aging: is it metabolic rate or stability?
Biogerontology,
6: 291-295; 2005.
148. Rattan, S.I.S. and Clark, B.F.C. Understanding and
modulating ageing.
IUBMB Life,
57: 297-304, 2005.
147. Rattan, S.I.S. Anti-ageing strategies: prevention
or therapy?
EMBO Reports,
6; S25-S29, 2005.
146. Rattan, S.I.S. and Sodagam, L. Gerontomodulatory
and youth-preserving effects of zeatin on human skin fibroblasts
undergoing aging in vitro. Rejuvenation
Research, 8: 46-57, 2005.
2004
145. Rattan, S.I.S. Aging intervention, prevention and
therapy through hormesis. Journals of Gerontology Biological Sciences,
59A: 705-709, 2004.
144. Rattan, S.I.S., Gonzalez-Dosal, R., Nielsen, E.R.,
Kraft, D.C., Weibel, J. and Kahns, S. Slowing down aging from within:
mechanistic aspects of anti-aging hormetic effects of mild heat stress on
human cells.
Acta
Biochimica Polonica, 51: 481-492, 2004.
143. Rattan, S.I.S. Hormetic mechanisms of anti-aging
and rejuvenating effects of repeated mild heat stress on human fibroblasts
in vitro. Rejuvenation Research, 7, 40-48, 2004.
142. Singh R, Kølvraa, S., Bross, P., Gregersen, N.,
Nexø, B.A., Frederiksen, H., Christensen, K. and Rattan, S.I.S.
Association between low self-rated health and heterozygosity for -110A>C
polymorphism in the promoter region of HSP70-1 in aged Danish twins.
Biogerontology, 5, 169-176, 2004.
141. Rattan, S.I.S. Mechanisms of hormesis through mild
heat stress on human cells. Annals of the New York Academy of Sciences,
1019: 554-558, 2004.
140. Rattan, S.I.S. Aging, anti-aging, and hormesis. Mechanisms of
Ageing and Development, 125,285-289, 2004.
139. Beedholm, R., Clark, B.F.C. and Rattan, S.I.S.
Mild heat stress stimulates 20S proteasome and its 11S activator in human
fibroblasts undergoing aging in vitro. Cell
Stress and Chaperones, 9, 49-57, 2004.
138. Rattan, S.I.S., Eskildsen-Helmond, Y. and Beedholm,
R. Molecular mechanisms of anti-aging hormetic effects of mild heat
stress on human cells. Non-Linearity in Biology, Toxicology and
Medicine, 2: 1-12, 2004.
2003
137. Rattan, S.I.S. Transcriptional and translational
dysregulation during aging. In: Aging at the Molecular Level. (edt:
T. von Zglinicki), pp. 179-191, Kluwer Academic Publishers, The
Netherlands, 2003.
136. Rattan, S.I.S. Aging outside the body: usefulness
of the Hayflick system. In: Aging of Cells Inside and Outside the
Body. (edt: S. Kaul and R. Wadhwa), pp. 1-8,Kluwer Academic
Publishers, The Netherlands, 2003.
135. Minois, N. and Rattan, S.I.S. Hormesis in aging
and longevity. In: Modulating Aging and Longevity (edt: S.I.S.
Rattan), pp. 127-137, Kluwer Academic Publishers, The
Netherlands, 2003.
134. Hercus, M., Loeschcke, V. and Rattan, S.I.S.
Extension of longevity of Drosophila by repeated mild heat stress
exposures, Biogerontology, 4, 149-156, 2003.
133. Rattan, S.I.S. Biology of aging and possibilities
of gerontomodulation. Proceedings of the Indian National Science
Academy, B69, 157-164, 2003.
2002
132. Rattan, S.I.S. A global view of the causes of
ageing. An interview with Robin Holliday. Biogerontology, 3,
317-324, 2002.
Co-endorser of the "Position Statement on Human
Aging", published as the weblink in the June issue of Scientific
American
(http://www.sciam.com/explorations/2002/051302aging/ )
131. Fonager, J., Beedholm, R., Clark, B.F.C. and
Rattan, S.I.S. Mild stress-induced stimulation of heat shock protein
synthesis and improved functional ability of human fibroblasts undergoing
aging in vitro. Experimental Gerontology, 37: 1223-1228.
130. Simonsen, J.L., Rosada, C., Serak, N., Justesen,
J., Stenderup, K., Rattan, S.I.S., Jensen, T.G. & Kassem, M. Telomerase
expression extends the proliferative life-span and maintains the
osteogenic potential of human bone marrow stromal cells.
Nature
Biotechnology, 20, 592-596, 2002.
129. Verbeke, P., Deries, M., Clark, B.F.C. & Rattan,
S.I.S. Hormetic action of mild heat stress decreases the inducibility of
protein oxidation and glycoxidation in human fiborblasts.
Biogerontology,3, 117-120, 2002.
128. Rattan, S.I.S. N6-furfuryladenine (kinetin) as a
potential anti-aging molecule. Journal of Anti-Aging Medicine, 5,
113-116, 2002.
2001
127. Verbeke, P., Clark, B.F.C. & Rattan, S.I.S.
Reduced levels of oxidized and glycoxidized proteins in human fibroblasts
exposed to repeated mild heat shock during serial passaging in vitro.
Free Radicals in Biology and Medicine, 31, 1593-1602, 2001.
126. Rattan, S.I.S. & Siboska, G. Kinetin: et
potentielt anti-aldringsmolekyle. Dansk Kemi, 82 (#11), 45-47, 2001. (in Danish)
125. Beedholm, R. & Rattan, S.I.S. Proteasomet.
Aktuel Naturvidenskab, 3 (#4), 4-6, 2001. (in Danish)
124. Rattan, S.I.S. "I no longer believe in
programmed aging", an interview with Vincent Cristofalo.
Biogerontology, 2, 283-290, 2001.
123. Rattan, S.I.S. Hormesis in biogerontology.
Critical Reviews in Toxicology, 31, 663-664, 2001.
122. Rattan, S.I.S. Ungdommens Kilde.
Aktuel
Naturvidenskab, 3 (#3), 25-27, 2001. (in Danish)
121. Verbeke, P., Fonager, J., Clark, B.F.C. & Rattan,
S.I.S. Heat shock response and ageing: mechanisms and applications. Cell Biology International, 25, 845-857, 2001.
120. Rattan, S.I.S. Applying hormesis in aging research
and therapy. Human and Experimental Toxicology, 20, 281-285, 2001.
first published in: BELLE Newsletter, 9, (3) 2-5, 2001. (with 10 expert
commentaries, and my response on pp. 28-29).
119. Stenderup, K., Justesen, J., Eriksen, E.F.,
Rattan, S.I.S. & Kassem, M. Number and proliferative capacity of
osteogenic stem cells are maintained during aging and in patients with
osteoporosis. Journal of Bone and Mineral Research, 16, 1120-1129,
2001.
118. Rattan, S.I.S. From vitagenes to gerontogenes and
the other way around: research strategies. In: Current
Concepts in Experimental Gerontology (Eds: C. Bertoni-Freddari and H. Niedermüller), pp. 15-22; Facultas Wien, 2001.
117. Kveiborg, M., Rattan, S.I.S., Clark, B.F.C.,
Eriksen, E.F. & Kassem M. Treatment with 1,25-dihydroxyvitamin D3 reduces
impairment of human osteoblast functions during cellular aging in culture.
Journal of Cellular Physiology, 186, 298-306, 2001.
2000
116. Barciszweski, J., Siboska, G., Rattan, S.I.S. &
Clark, B.F.C. Occurrence, biosynthesis and properties of kinetin
(N6-furfuryladenine). Plant Growth Regulation, 32, 257-265, 2000.
115. Barciszweski, J., Siboska, G., Clark, B.F.C &
Rattan, S.I.S. Cytokinin formation by oxidative metabolism. Journal of
Plant Physiology, 157, 587-588, 2000.
114. Kveiborg, M., Flyvbjerg, A., Rattan, S.I.S. &
Kassem M. Changes in the insulin-like growth factor-system may contribute
to in vitro age-related impaired osteoblast functions. Experimental
Gerontology, 35, 1061-1074, 2000.
113. Verbeke, P., Clark, B.F.C. & Rattan, S.I.S.
Modulating cellular aging in vitro:hormetic effects of repeated mild heat
stress on protein oxidation and glycation.
Experimental Gerontology,
35, 787-794, 2000.
112. Verbeke, P., Siboska, G.E., Clark, B.F.C. &
Rattan, S.I.S. Kinetin inhibits protein oxidation and glycoxidation in
vitro. Biochemical and Biophysical Research Communications, 276,
1265-1270, 2000.
111. Rattan, S.I.S. "Just a fellow who did his
job...", an interview with Leonard Hayflick.
Biogerontology, 1,
79-87, 2000.
110. Rattan, S.I.S. & Kveiborg, M. Alderdomsbiologi -
det naeste skridt. Aktuel Naturvidenskab, 2 (#4), 4-6, 2000. (in Danish)
109. Christiansen, M., Stevnsner, T., Bohr, V.A.,
Clark, B.F.C. and Rattan, S.I.S. Gene-specific DNA repair of pyrimidine
dimers does not decline during cellular aging in vitro. Experimental
Cell Research, 256, 308-314, 2000.
108. Christiansen, M., Kveiborg, M., Kassem, M., Clark,
B.F.C. and Rattan, S.I.S. CBFA1 and topoisomerase I mRNA levels decline
during cellular aging of human trabecular osteoblasts. Journals of
Gerontology: Biological Sciences, 55A, B194-B200, 2000.
107. Rattan, S.I.S. Biogerontology: the next step.
Annals of the New York Academy of Sciences, 908, 282-290, 2000.
106. Rattan, S.I.S. Gerontogenes, ageing, and
hormesis. Indian Journal of Experimental Biology, 38, 1-5, 2000.
1999
105. Olsen, A., Siboska, G.E., Clark, B.F.C. and
Rattan, S.I.S. N6-furfuryladenine, kinetin, protects against Fenton
reaction-mediated oxidative damage to DNA. Biochemical and Biophysical
Research Communications, 265: 499-502, 1999.
104. Kveiborg, M., Kassem, M., Langdahl, B., Eriksen,
E.F., Clark, B.F.C. and Rattan, S.I.S. Telomere shortening during aging of
human osteoblasts in vitro and leucocytes in vivo: lack of excessive
telomere loss in osteoporotic
patients. Mechanisms of Ageing and Development, 106:
261-271, 1999.
103. Barciszewski, J., Barciszewska, M., Siboska, G.,
Rattan, S.I.S. and Clark, B.F.C. Some unusual nucleic acid bases are
products of hydroxyl radical oxidation of DNA and RNA. Molecular
Biology Reports, 26, 31-38, 1999.
102. Barciszewski, J., Rattan, S.I.S., Siboska, G. and
Clark, B.F.C. Kinetin - 45 years on.
Plant Science, 148, 37-45, 1999.
101. Rattan, S.I.S. Ageing genes: gerontogenes.
Encyclopaedia of Life Sciences, (Macmillan Press, UK), Article # 3059;
1999
100. Rattan, S.I.S. Cellular senescence in vitro.
Encyclopaedia of Life Sciences, (Macmillan Press, UK), Article # 2567;
1999.
99. Rattan, S.I.S. and Clark, B.F.C. Protein synthesis,
post-translational modifications and aging. Alfred Benzon Symposium,
44,320-331, 1999.
1998
97. Rattan, S.I.S. Repeated mild heat shock delays
ageing in cultured human skin fibroblasts. Biochemistry and Molecular
Biology International, 45, 753-759, 1998.
96. Gonos, E.S., Derventzi, A., Kveiborg, M.,
Agiostratidou, G., Kassem, M., Clark, B.F.C., Jat, P.S. and Rattan, S.I.S.
Cloning and identification of genes that associate with mammalian
replicative senescence. Experimental Cell
Research, 240, 66-74, 1998.
95. Rattan, S.I.S. Is gene therapy for aging possible?
Indian Journal of Experimental Biology, 36, 233-236, 1998.
94. Rattan, S.I.S.Molecular, cellular and genetic
determinants of aging. Aging: Clinical and Experimental Research, 9,
430-432.
93. Rattan, S.I.S.The nature of gerontogenes and
vitagenes. Antiaging effects of repeated heat shock on human fibroblasts.
Annals of the New York Academy of Sciences, 854, 54-60, 1998.
1997
92. Sharma, S.P., Kaur, J. and Rattan, S.I.S.Increased
longevity of kinetin-fed Zaprionus fruitflies is accompanied by their
reduced fecundity and enhanced catalase activity. Biochemistry and
Molecular Biology International, 41, 869-875, 1997.
91. Barciszewski, J., Siboska, G.E., Pedersen, B.O.,
Clark, B.F.C. and Rattan, S.I.S. Furfural, a precursor of the cytokinin
hormone kinetin, and base propenals are formed by hydroxy radical damage
of DNA. Biochemical and
Biophysical Research Communications, 238, 317-319,
1997.
90. Barciszewski, J., Siboska, G.E., Pedersen, B.O.,
Clark, B.F.C. and Rattan, S.I.S. A mechanism for the in vivo formation of
kinetin as a secondary oxidative damage product in DNA.
FEBS Letters,
414, 457-460, 1997.
89. Kassem, M., Ankersen, L., Eriksen, E.F., Clark,
B.F.C. and Rattan, S.I.S. Demonstration of cellular aging and senescence
in serially passaged long term cultures of human trabecular osteoblasts.
Osteoporosis International, 7,
514-524, 1997.
88. Rattan, S.I.S. Gene therapy for ageing: mission
impossible? Human Reproduction and Genetic Ethics, 3, 27-29, 1997.
87. Rattan, S.I.S. and Christiansen, M.Genterapi mod
aldring: muligt eller ej? Ugeskrift for Læger, 159, 6381-6383, 1997.
(in Danish)
86. Rattan, S.I.S. Genes for aging: gerontogenes.In:
Molecular Biology of Development and Aging. (ed.: M.S. Kanungo), pp.
97-102, New Age Int. Pbl., New Delhi, India, 1997.
1996
85. Riis, B. and Rattan, S.I.S.The antibiotic fusidic
acid inhibits ADP-ribosylation of protein elongation factor-2 in human
cells. Medical Science Research, 24, 221-222, 1996.
84. Norsgaard, H., Rattan, S.I.S. and Clark, B.F.C.
Distinction between differentiation and senescence and the absence of
increased apoptosis in human keratinocytes undergoing cellular aging in
vitro. Experimental Gerontology, 31, 563-570, 1996.
83. Barciszewski, J., Siboska, G.E., Pedersen, B.O.,
Clark, B.F.C. and Rattan, S.I.S. Evidence for the presence of kinetin in
DNA and cell extracts. FEBS Letters, 393, 197-200, 1996.
82. Rattan, S.I.S. Cellular and molecular determinants
of ageing. Indian Journal of Experimental Biology, 34, 1-6, 1996.
81. Rattan, S.I.S. and Kveiborg, M. Aldring i
reagensglas: hvilken relevans? Gerontologi og Samfund, 12, 15-16,1996.
(in Danish)
80. Rattan, S.I.S. Synthesis, modifications and
turnover of proteins during cellular aging. Experimental Gerontology,
31, 33-47, 1996.
79. Rattan, S.I.S. Cellular ageing in vitro as the
basis of understanding ageing in vivo. Facts and Research in
Gerontology, 5, 7-17, 1996.
78. Rattan, S.I.S. and Clark, B.F.C. Intracellular
protein synthesis, modifications and aging. Biochemical Society
Transactions, 24, 1043-1049, 1996.
77. Derventzi, A., Rattan, S.I.S. and Gonos,
E.S.Molecular links between cellular mortality and immortality.
Anticancer Research, 16, 2901-2910, 1996.
76. Derventzi, A., Gonos, E.S. and Rattan, S.I.S.Ageing
and cancer - a struggle of tendencies.In: Molecular Gerontology -
Research Status and Strategies. (eds.: S.I.S. Rattan and O.
Toussaint), pp. 15-23, Plenum Press, New York, USA, 1996.
75. Andersen, L.B., Lund, A., Kveiborg, M., Clark,
B.F.C. and Rattan, S.I.S. From genes to functional gene products during
ageing.In: Molecular Gerontology - Research Status and Strategies.
(eds.: S.I.S. Rattan and O. Toussaint), pp.53-73, Plenum Press, New York,
USA, 1996.
74. Toussaint, O. and Rattan, S.I.S. From molecular
gerontology to healthy old age.In: Molecular Gerontology - Research Status
and Strategies. (eds.: S.I.S. Rattan and O. Toussaint), pp. 201-209,
Plenum Press, New York, USA,
1996.
1995
73. Riis, B., Rattan, S.I.S., Palmquist, K., Clark,
B.F.C. and Nygård, O. Dephosphorylation of the phosphorylated elongation
factor-2 in the livers of calorie-restricted and freely-fed rats during
ageing. Biochemistry and Molecular Biology International, 35, 855-859,
1995.
72. Barciszewski, J., Barciszewska, M.Z., Rattan, S.I.S.
and Clark, B.F.C.The structure and properties of 8-hydroxydeoxyguanosine -
novel biomarker in aging and carcinogenesis studies. Polish Journal of
Chemistry, 69, 841-851, 1995.
71. Levels of oxidative DNA damage product
8-hydroxy-2’-deoxyguanosine in human serum increase with age. Medical
Science Research, 23, 469-470, 1995.
70. Sharma, S.P., Kaur, P. and Rattan, S.I.S.Plant
growth hormone kinetin delays ageing, prolongs the lifespan and slows down
development of the fruitfly Zaprionus paravittiger.Biochemical and
Biophysical Research
Communications, 216, 1067-1071, 1995.
69. Rattan, S.I.S.Gerontogenes: real or virtual?
FASEB J. 9, 284-286, 1995.
68. Rattan, S.I.S. Cellular and molecular basis of
aging.In: Hormones and Aging (eds: P.S. Timiras, W.B. Quay & A.Vernadakis),
pp. 267-290, CRC Press, Boca Raton, USA, 1995.
67. Rattan, S.I.S.Translation and post-translational
modifications during aging.In: Molecular Basis of Aging (ed: A.Macieira-Coelho),
pp. 389-420, CRC Press, Boca Raton, USA, 1995.
66. Rattan, S.I.S.Protein synthesis and regulation in
eukaryotes.In: Principles of Medical Biology , vol. 4, Cell Chemistry and
Physiology (eds: E.E. Bittar & N. Bittar), pp. 247-263, JAI Press Inc.,
USA, 1995.
65. Rattan, S.I.S. Ageing ? a biological perspective.
Molecular Aspects of Medicine, 16, 439-508, 1995.
64. Rattan, S.I.S.Genes for ageing: gerontogenes.In:
Proceedings of the EU Conference onThe Human Genome in Europe: Scientific,
Ethical & Social Aspects. pp 32-36, Académie Royale de Médecine de
Belgique, Brussels, 1995.
1994
63. Ankersen, L., Kassem, M., Ostergaard, L.H., Eriksen,
E.E., Clark, B.F.C. and Rattan, S.I.S.Aging of human trabecular
osteoblasts in culture. Archives of Gerontology and Geriatrics, suppl.
4, 5-12, 1994.
62. Norsgaard, H., Glenting, M., Kristensen, P. Clark,
B.F.C. and Rattan, S.I.S.Aging, differentiation and apoptosis in human
epidermal keratinocytes in culture. Archives of Gerontology and
Geriatrics, suppl. 4, 185-196, 1994.
61. Svendsen, L., Rattan, S.I.S. and Clark,
B.F.C.Testing garlic for possible anti-ageing effects on long-term growth
characteristics, morphology and macromolecular synthesis of human
fibroblasts in culture. Journal of
Ethnopharmacology, 43, 125-133, 1994.
60. Rattan, S.I.S. and Clark, B.F.C. Kinetin delays the
onset of ageing characteristics in human fibroblasts. Biochemical and
Biophysical Research Communications, 201, 665-672, 1994.
59. Rattan, S.I.S. and Stacey, G.N.
The uses of diploid
cell strains in research in aging.In: Cell and Tissue Culture: Laboratory
Procedures (eds: J.B. Griffiths, A. Doyle & D.G. Newell), Part 6D, pp.
2.1-2.12, John Wiley, UK, 1994.
1993
58. Barciszewski, J., Rattan, S.I.S., Siboska, G.E.,
Otzen, D.E. and Clark, B.F.C.Reduction in the amount of
8-hydroxy-2´-deoxyguanosine in the DNA of SV40-transformed
human fibroblasts as compared with normal cells in
culture. FEBS Letters, 318, 186-188, 1993.
57. Derventzi, A., Rattan. S.I.S. and Clark,
B.F.C.Phorbol ester PMA stimulates protein synthesis and increases the
levels of active elongation factors EF-1a and EF-2 in ageing human
fibroblasts. Mechanisms of Ageing and
Development, 69, 193-205, 1993.
56. Riis, B., Rattan, S.I.S., Palmquist, K., Nilsson,
A., Nygård, O. and Clark, B.F.C. Elongation factor 2-specific calcium and
calmodulin dependent protein kinase III activity in rat livers varies with
age and calorie restriction.
Biochemical and Biophysical Research Communications,
192, 1210-1216, 1993.
55. Johansen, L.B and Rattan, S.I.S.Protein synthesis
and aging. Reviews in Clinical Gerontology, 3, 3-12, 1993.
54. Rattan, S.I.S. and Ankersen, L. Hvad er
gerontogener? Gerontologi og Samfund, 9, 24-25, 1993. (in Danish)
1992
53. Derventzi, A., Rattan, S.I.S. and Clark,
B.F.C.Phorbol ester-induced reorganization of the cytoskeleton in human
fibroblasts during ageing in vitro. Biochemical Biophysical Research
Communications, 182, 1423-1428, 1992.
52. Derventzi, A., Rattan. S.I.S. and Clark, B.F.C.
Senescent human fibroblasts are more sensitive to the effects of a
phorbol ester on macromolecular synthesis and growth
characteristics. Biochemistry International, 27, 903-911, 1992.
51. Barciszewski, J., Otzen, D., Rattan, S.I.S. and
Clark, B.F.C. Specific incorportation of kinetin into eukaryotic and
prokaryotic transfer ribonucleic acid molecules.
Biochemistry International, 28, 805-811, 1992.
50. Rattan, S.I.S. Regulation of protein synthesis
during ageing. European Journal of Gerontology, 1, 128-136, 1992.
49. Rattan, S.I.S., Derventzi, A. and Clark,
B.F.C.Protein synthesis, post-translational modifications and aging.
Annals of the New York Academy of Sciences, 663, 48-62,
1992.
48. Rattan, S.I.S. and Riis, B. Why we grow old.In:
Realm of Differentiation (ed. M. Habibulla), pp 87-93,Neelkanth
Publishers, New Delhi, India, 1992.
1991
47. Rattan, S.I.S., Ward, W.F., Glenting, M., Svendsen,
L., Riis, B. and Clark, B.F.C. Dietary calorie restriction does
not affect the levels of protein elongation factors in rat
livers during ageing. Mechanisms of Ageing and Development,
58, 85-91, 1991.
46. Rattan, S.I.S. Aging and disease: proteins as the
molecular link. Perspectives in Biology and Medicine, 34, 526-533,
1991.
45. Rattan, S.I.S. and Derventzi, A. Altered cellular
responsiveness during ageing. BioEssays, 13, 601-606, 1991.
44. Rattan, S.I.S.Protein synthesis and the components
of protein synthetic machinery. Mutation Research, 256,
115-125, 1991.
43. Derventzi, A. and Rattan, S.I.S. Homeostatic
imbalance during cellular ageing: altered responsiveness. Mutation
Research, 256, 190-202, 1991.
42. Rattan, S.I.S. and Derventzi, A. Gene expression
during ageing: protein synthesis and post-translational
modifications. Topics in Aging Research in Europe,
16,133-142, 1991.
1990
41. Riis, B., Rattan, S.I.S., Derventzi, A. and Clark,
B.F.C. Reduced levels of ADP-ribosylatable elongation factor-2 in
aged and SV40-transformed human cells. FEBS Letters, 266,
45-47, 1990.
40. Rattan, S.I.S. and Riis, B.Er vores livetid
programmeret? Gerontologi og Samfund, 6, 6-8, 1990. (in Danish)
39. Riis, B., Rattan, S.I.S., Clark, B.F.C. and
Merrick, W.C. Eukaryotic protein elongation factors. Trends in
Biochemical Sciences (TIBS), 15, 420-424, 1990.
38. Rattan, S.I.S. and Kristensen, O. Continuous gene
expression in vitro: the Spirin system. Trends in Biotechnology,
8, 275-276, 1990.
1989
37. Riis, B., Rattan, S.I.S., Cavallius, J, & Clark,
B.F.C. ADP-ribosylatable content of elongation factor-2 changes
during cell cycle of normal and cancerous human cells.
Biochemical and Biophysical Research Communications, 159,
1141-1146, 1989.
36. Riis, B., Rattan, S.I.S., Cavallius, J. and Clark,
B.F.C. Levels of active elongation factor-2 in rat livers during
ageing. Topics in Aging Research in Europe, 13, 117-124,
1989.
35. Cavallius, J., Rattan, S.I.S. & Clark, B.F.C.A
decrease in levels of mRNA for elongation factor-1a accompanies the
decline in its activity and the amounts of active enzyme
in rat livers during ageing. Topics in Aging Research in Europe,
13, 125-132, 1989.
34. Riis, B., Rattan, S.I.S. and Clark,
B.F.C.Estimating the amounts of ADP-ribosylatable elongation factor-2 in
mammalian cell-free extracts. Journal of Biochemical and
Biophysical Methods 19, 319-326, 1989.
33. Rattan, S.I.S. DNA damage and repair during
cellular aging. International Review of Cytology, 116, 47-88, 1989.
32. Rattan, S.I.S. Going in circles: what future for
ageing research? BioEssays, 11, 3-4, 1989.
31. Riis, B. and Rattan, S.I.S.Alderdom og biokemi.
Naturens Verden, No. 9, 329-336, 1989. (in Danish)
30. Rattan, S.I.S. and Riis, B.Biokemisk forskning i
alderdom, hvorfor? Ugeskrift for Læger, 151, 3085-3086, 1989. (in
Danish)
1988
29. Rattan, S.I.S., Rasmussen, L.M., Bjerring, P.,
Bhatia, P. & Clark, B.F.C. Human plasma fibronectin levels during
ageing, Alzheimer ´s disease and cancer. Trends in
Biomedical Gerontology, 1, 61-62, 1988.
28. Rattan, S.I.S., Cavallius, J., Madsen, A.,
Hartvigen, G. & Clark, B.F.C. Inhibition of protein elongation factor-1a
during heat shock of ageing and immortal human cells.
Trends in Biomedical Gerontology, 1, 195-196, 1988.
27. Rattan, S.I.S., Rasmussen, L.M., Bjerring, P.,
Bhatia, P. & Clark, B.F.C.Unchanged concentrations of plasma
fibronectin in Alzheimer's disease. Journal of Clinical
Pathology, 41, 476, 1988.
26. Rattan, S.I.S., Cavallius, J. & Clark, B.F.C. Heat
shock-related decline in amounts of active elongation factor-1a
and its activity in ageing and immortal human cells.
Biochemical and Biophysical Research Communications, 152,
169-176, 1988.
25. Rattan, S.I.S. & Clark, B.F.C.Ageing: a challenge
for biotechnology. Trends in Biotechnology, 6, 58-62, 1988.
24. Rattan, S.I.S. Science behind spices: inhibition of
platelet aggregation and prostaglandin synthesis. BioEssays, 8,
161-162, 1988.
23. Rattan, S.I.S. Finding differences in biochemistry:
the case of ageing. Trends in Biotechnology, 6, 267-268, 1988.
1987
22. Bhatia, P., Rattan, S.I.S., Cavallius, J., & Clark,
B.F.C.Withania somnifera (Ashawagandha), a so-called
rejuvenator, inhibits growth and macromolecular synthesis
of human cells. Medical Science Research, 15, 515-516,
1987.
21. Rattan, S.I.S. & Bhatia, P. Genetic engineering:
Fact, fiction and future. Indo-European Medical Journal, 2, (2),
27-29, 1987.
20. Rattan, S.I.S., Cavallius, J., Bhatia, P. & Clark,
B.F.C. Protein elongation factor-1a in ageing rodent brain. In:
Aging - a multifactorial discussion (eds. K. Subba Rao &
V. Prabhakar) pp 125-130, Association of Gerontology
Publishers, India, 1987.
1986
19. Rattan, S.I.S., Cavallius, J., Coppard, N.J.,
Mosses, D., Madsen, A. & Clark, B.F.C. Post-translational
methylation of elongation factor-1a in ageing and immortal
human cells. Topics in Aging Research in Europe, 7,
132-145, 1986.
18. Cavallius, J., Rattan, S.I.S. & Clark, B.F.C.
Changes in activity and amount of active elongation factor-1a in aging
and immortal human fibroblast cultures. Experimental
Gerontology, 21,149-157, 1986.
17. Rattan, S.I.S., Cavallius, J., Hartvigsen, G. &
Clark, B.F.C.Amounts of active elongation factor-1a and its activity
in livers of mice during ageing. Trends in Aging Research/
Colloque INSERM. 147, 135-140, 1986.
16. Rattan, S.I.S. Ageing and immortality. BioEssays,
4, 82-83, 1986.
15. Rattan, S.I.S. Ageing trends and the European
effort. BioEssays, 5, 51-52, 1986.
1985
14. Holliday, R., Thompson, K.V.A., Huschtscha, L.I.,
Rattan, S.I.S., Sedgwick, S.G. & Spanos, A. Experimental
studies on Werner's syndrome fibroblasts. Advances in
Experimental Medicine and Biology, 190, 331-339, 1985.
13. Rattan, S.I.S. Beyond the present crisis in
gerontology. BioEssays, 2, 226-228, 1985.
1984
12. Holliday, R. & Rattan, S.I.S. Evidence that
paromomycin induces premature ageing of human fibroblasts in
culture. Monographs in Developmental Biology, 17, 221-233,
1984.
11. Rattan, S.I.S.RNA recombination: a breakthrough in
genetic engineering. Science Reporter, 21, 330-332, 1984.
1983
10. Rattan, S.I.S. Ageing outside the body. Science
Today, 17 (8), 52-55, 1983.
1982
9. Rattan, S.I.S. & Buchanan, J.H. Optimum conditions
for growth and longevity of chick embryo fibroblasts in culture.
Mechanisms of Ageing and Development, 19, 1-4, 1982.
8. Rattan, S.I.S., Keeler, K.D., Buchanan, J.H. &
Holliday, R. Autofluorescence as an index of ageing in human
fibroblasts in culture. Bioscience Reports, 2, 561-567,
1982.
7. Rattan, S.I.S. Uptake, accumulation and release of
paromomycin by human fibroblasts in culture.
IRCS Medical Sciences, 10, 807-808, 1982.
6. Buchanan, J.H., Rattan, S.I.S., Stevens, A. &
Holliday, R.Intracellular accumulation of a fluorescsent derivative of
paromomycin in human fibroblasts. Journal of Cellular
Biochemistry, 20, 71-82, 1982.
1979
5. Rattan, S.I.S. & Mookerjee, S.Altered profiles of
RNA synthesis in a dimethyl sulphate mutant hydra. Indian Journal
of Experimental Biology, 17, 1007-1011, 1979.
4. Sharma, S.P., Rattan, S. & Sharma, G.Temperature
dependent longevity of Zabrotes subfasciatus Boh. (Col.
Bruch.). Comparative Physiology and Ecology, 4, 229-231,
1979.
1977
3. Sharma, S.P., Sharma, G. & Rattan, S. The biological
phenomenon of ageing. Everyday Science,22 (3), 1-4, 1977.
1976
2. Sharma, S.P. & Rattan, S.Lipofuscin - an index of
ageing. Everyday Science, 21 (4), 35-36, 1976.
1. Sharma, S.P. & Rattan, S. Lysosome - the suicidal
bag. Everyday Science,21 (2), 39-43, 1976.
